Cocaine worth an estimated £5m has been seized from a cargo ship at Immingham Docks in Lincolnshire.
The drugs were found on a cargo vessel carrying coal which had travelled to the UK from Puerto Prodeco, Colombia, via The Netherlands on Monday.
Border Force officials discovered the 45kg haul at about 06:00 BST and said the drugs would now be destroyed.
The UK Border Agency said no arrests had yet been made.
The agency said it was the latest in a series of interceptions to take place at Immingham in recent months.
In June, cocaine worth £1m was seized from a ship that had also travelled from Colombia.
Four illegal Albanian stowaways were also stopped at the port last month and denied entry to the UK.